Lymphoma

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Lymphoma

Lymphoma is a general term for malignancies of lymphocytes or, more rarely, of histiocytes. Collectively, these cell types form the reticuloendothelial system and circulate in the vessels of the lymphatic system. Traditionally, Lymphoma is classified as Hodgkin's disease, discovered by Thomas Hodgkin in 1832, and non-Hodgkin's lymphoma (all other types of lymphoma). Modern classifications of lymphoma have moved away from this artificial division.


Classification
The Working Formulation, published in 1982, is primarily descriptive but remains the most widely used classification of non-Hodgkin lymphoma today.

Low Grade
Malignant Lymphoma, small lymphocytic (chronic lymphocytic leukemikaka)
Malignant Lymphoma, follicular, predominantly small cleaved cell
Malignant Lymphoma, follicular, mixed (small cleaved and large cell)
Intermediate Grade
Malignant Lymphoma, follicular, predominantly large cell
Malignant Lymphoma, diffuse, small cleaved cells
Malignant Lymphoma, diffuse, mixed (small and large cells)
Malignant Lymphoma, diffuse large cells
High Grade
Malignant Lymphoma, large cell, immunoblastic
Malignant Lymphoma, lymphoblastic
Malignant Lymphoma, small non-cleaved cells (Burkitt's lymphoma)
Miscellaneous
Composite
Mycosis fungoides
Histiocytic
Extramedullary plasmacytoma
Unclassifiable
The WHO Classification is the latest classification of lymphoma, published by the World Health Organization in 2001. This classification attempts to classify lymphomas by cell type, i.e. the normal cell type that most closely resembles the tumour. They are classified in three large groups: the B cell tumours, the T cell and natural killer cell tumours, Hodgkin lymphoma, and other minor groups:

Mature B Cell Neoplasms
Chronic lymphocytic leukemia/small lymphocytic lymphoma
B-cell prolymphocytic leukaemia
Lymphoplasmacytic lymphoma/Waldenström macroglobulinemia
Splenic marginal zone lymphoma
Plasma cell neoplasms
Plasma cell myeloma
Plasmacytoma
Monoclonal immunoglobulin deposition diseases
Heavy chain diseases
Extranodal marginal zone B cell lymphoma (MALT lymphoma)
Nodal marginal zone B cell lymphoma
Follicular lymphoma
Mantle cell lymphoma
Diffuse large B cell lymphoma
Mediastinal (thymic) large B cell lymphoma
Intravascular large B cell lymphoma
Primary effusion lymphoma
Burkitt lymphoma/leukemia
lymphomatoid granulomatosis
Mature T cell and Natural Killer (NK) Cell Neoplasms
T cell prolymphocytic leukemia
T cell large granular lymphocytic leukemia
Agressive NK cell leukemia
Adult T cell leukemia/lymphoma
Extranodal NK/T cell lymphoma, nasal type
Enteropathy-type T cell lymphoma
Hepatosplenic T cell lymphoma
Blastic NK cell lymphoma
Mycosis fungoides/Sezary syndrome
Primary cutaneous CD30-positive T cell lymphoproliferative disorders
Primary cutaneous anaplastic large cell lymphoma
Lymphomatoid papulosis
Angioimmunoblastic T cell lymphoma
Peripheral T cell lymphoma, unspecified
Anaplastic large cell lymphoma
Hodgkin Lymphoma
Nodular lymphocyte-predominant Hodgkin lymphoma
Classical Hodgkin lymphoma
Nodular sclerosis
Mixed cellularity
Lymphocyte-rich
Lymphocyte depleted
Immnuodeficiency-Associated Lymphoproliferative Disorders
Associated with a primary immune disorder
Associated with the Human Immunodeficiency Virus (HIV)
Post-transplant
Associated with Methotrexate therapy
Histiocytic and Dendritic Cell Neoplasms
Histiocytic sarcoma
Langerhans cell histiocytosis
Langerhans cell sarcoma
Interdigitating dendritic cell sarcoma/tumour
Follicular dendritic cell sarcoma/tumour
Dendritic cell sarcoma, unspecified

Prevalence
According to the U.S. National Institutes of Health, lymphomas account for about five percent of all cases of cancer in the United States, and Hodgkin's disease in particular accounts for less than one percent of all cases of cancer in the United States.
From Wikipedia, the free encyclopedia.
>>http://en.wikipedia.org/wiki/Lymphoma










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